Protein Explorer
Model & correlation settings
Control which confounders to regress out. Aβ/Tau correction removes variance explained by amyloid/tau pathology.
These checkboxes affect how correlations are computed in the Scatter and Cell Markers tabs. All groups are still shown in the visualizations.
Age trend
Aβ trend (APP)
Tau trend (MAPT)
Abundance by NIA-Amyloid
Abundance by Braak stage
Similar genes (click to show scatter)
Scatter plot
Correlation with Cell/Subcellular Markers
Marker Scatter (click bar to plot)
Cellular Decomposition PCA
PC1
PC2
PC3
PC4
Differential Correlations
Proteins with the most significant correlation changes between conditions. Bars show correlation range; ● = condition 1, ■ = condition 2.
Association Statistics
Without cell composition correction
Aβ peptide
Tau (MAPT)
Age
With cell composition correction
Aβ peptide
Tau (MAPT)
Age
Association Explorer
Browse all protein associations. Click a protein to explore in detail.
Correlation shows Pearson r between protein abundances. Synergy measures whether a protein pair separates AD / Control / 100+ better together than either protein alone (between/within variance; synergy = S(P1,P2) − max(S(P1), S(P2))). Hover highlights proteins in the volcano plot; click a cell to open the protein scatter.
Peptide Explorer
Protein Structure & Peptide Alignment
Scroll to pan. Use buttons or mouse wheel (with Ctrl) to zoom. Bold letters = trypsin cleavage sites (K/R). Red dashed outline = not fully tryptic (one or both termini not cleavage-compatible for that isoform). Red letters = common variants. Colored regions = protein domains.
Peptide Details
| Peptide | Clean Sequence | Position | Isoform Alignments |
|---|
Values shown are log2 peptide abundance (not covariate-corrected).
Missing Values by Peptide
Fraction of missing/zero values per peptide, by group
Mean Abundance by Peptide
Average log2 abundance per peptide, by group. Stars indicate significance vs Control.
Peptide-Peptide Correlation Matrix
Click on a cell to see scatter plot of the two peptides
Peptide Scatter
Click a cell in the correlation matrix to view scatter plot